CLINICAL TRIALS AND OBSERVATIONS In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study
نویسندگان
چکیده
Departments of 1Dermatology and 2Pathology, Stanford University School of Medicine, Stanford, CA; 3Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA; 4Division of Hematology/Oncology, University of California–San Francisco, San Francisco; 5Department of Health Research Policy and Statistics, Stanford University, Stanford, CA; and 6Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA
منابع مشابه
Brentuximab as a treatment for CD30+ mycosis fungoides and Sézary syndrome.
IMPORTANCE The prognosis of advanced cutaneous T-cell lymphoma (CTCL), including Sézary syndrome and mycosis fungoides (MF), is poor. So far, no curative option apart from allogeneic stem cell transplantation is available. Large cell transformation often hallmarks cases with a more aggressive clinical course, and large tumor cells may express CD30. Recently, brentuximab vedotin, a conjugate of ...
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By HENRY H. HENSTELL, M.D., JEROME N. TOBER, M.D., AND BEN A. NEWMAN, M.D. T HIS report deals with the therapeutic effect of nitrogen mustard on 6 patients with mycosis fungoides. The nitrogen mustards, i.e., the B-chloroethylamines, of which the methyl-bis form is being studied clinically, has been shown to be effective in the control of certain types of malignancies.’4 The effects of this gro...
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متن کاملCLINICAL TRIALS AND OBSERVATIONS Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation
Although mycosis fungoides (MF) is typically an indolent disease, patients with advanced-stage disease (stages IIB-IVB), including Sézary syndrome (SS), often have a poor outcome. A 31-year, retrospective analysis of our cutaneous lymphoma database, of 297 patients with MF and SS, was undertaken to study longterm outcomes and identify clinical predictors of outcome in patients with advanced-sta...
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It is now widely accepted that polymerase chain reaction (PCR) analysis of cutaneous T-cell clonality is of diagnostic value in cutaneous T-cell lymphomas (CTCLs) and most helpful in the diagnosis of mycosis fungoides (MF). However, the diagnostic and prognostic value of circulating clonal T cells remains unclear. We studied T-cell clonality in the peripheral blood (PB) and the cutaneous lesion...
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